{"id":1607,"date":"2026-03-14T12:46:00","date_gmt":"2026-03-14T12:46:00","guid":{"rendered":"https:\/\/blooducation.co.uk\/?p=1607"},"modified":"2026-03-14T12:46:10","modified_gmt":"2026-03-14T12:46:10","slug":"clinical-use-of-granulocytes-dr-suzy-morton","status":"publish","type":"post","link":"https:\/\/blooducation.co.uk\/clinical-use-of-granulocytes-dr-suzy-morton","title":{"rendered":"Clinical use of granulocytes &#8211; Dr Suzy Morton"},"content":{"rendered":"\n<p><strong>Granulocytes in England are unusual as they are provided as a component pooled from whole blood. Helen and Suzy discuss when their use should be considered and what to watch out for when using them<\/strong><\/p>\n\n\n<p><iframe style=\"border: none;\" src=\"\/\/html5-player.libsyn.com\/embed\/episode\/id\/16218947\/height\/90\/theme\/custom\/thumbnail\/no\/direction\/backward\/render-playlist\/no\/custom-color\/87A93A\/\" width=\"100%\" height=\"90\" scrolling=\"no\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n\n\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"542\" height=\"460\" src=\"https:\/\/blooducation.co.uk\/wp-content\/uploads\/2020\/01\/PBM_Smaller.jpg\" alt=\"\" class=\"wp-image-1191\" srcset=\"https:\/\/blooducation.co.uk\/wp-content\/uploads\/2020\/01\/PBM_Smaller.jpg 542w, https:\/\/blooducation.co.uk\/wp-content\/uploads\/2020\/01\/PBM_Smaller-300x255.jpg 300w, https:\/\/blooducation.co.uk\/wp-content\/uploads\/2020\/01\/PBM_Smaller-140x120.jpg 140w, https:\/\/blooducation.co.uk\/wp-content\/uploads\/2020\/01\/PBM_Smaller-70x60.jpg 70w, https:\/\/blooducation.co.uk\/wp-content\/uploads\/2020\/01\/PBM_Smaller-20x16.jpg 20w, https:\/\/blooducation.co.uk\/wp-content\/uploads\/2020\/01\/PBM_Smaller-150x127.jpg 150w\" sizes=\"(max-width: 542px) 100vw, 542px\" \/><\/figure>\n\n\n\n<p>Granulocyte component<\/p>\n\n\n\n<p>Pooled from 10 whole blood donations \u2192 buffy coats \u2192 red cell and platelet reduced \u2192 one bag with plasma and PAS.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Vol ~200ml per bag<\/li>\n\n\n\n<li>9 x109 granulocytes\/bag (grans)<\/li>\n\n\n\n<li>5 units of platelets per bag<\/li>\n\n\n\n<li>15g hb per unit; hct 0.15<\/li>\n\n\n\n<li>Stored at room temperature<\/li>\n\n\n\n<li>Transfuse by midnight the day after donation<\/li>\n\n\n\n<li>Irradiated<\/li>\n<\/ul>\n\n\n\n<p>Usual dose 2-3 bags (20 ml\/kg in children)<\/p>\n\n\n\n<p>Historically supplied Tues-Sat. Now limited availability of&nbsp; O pos on Mondays. If D neg woman of child bearing potential consider anti D cover (see guidelines)<\/p>\n\n\n\n<p>Apheresis granulocytes used internationally \u2013 stimulate donors with GCSF +\/- dexamethasone \u2013 not acceptable for non directed donations in the UK. Previously done at Kings and Bristol but not more recently.<\/p>\n\n\n\n<p><a href=\"https:\/\/hospital.blood.co.uk\/components\/portfolio-and-prices\/\">NHSBT portfolio of blood components<\/a><\/p>\n\n\n\n<p>Indications for granulocytes<\/p>\n\n\n\n<p>NHSBT guidelines state granulocytes can be given if<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Neutrophils &lt;0.5 x109 due to congenital or acquired bone marrow failure<\/li>\n\n\n\n<li>Having definitive treatment<\/li>\n\n\n\n<li>Severe refractory bacterial or fungal infection<\/li>\n\n\n\n<li>Neutrophil recovery anticipated<\/li>\n<\/ul>\n\n\n\n<p>Can also give for congenital neutrophil dysfunction.<\/p>\n\n\n\n<p>No allowance for e.g.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>acquired neutrophil dysfunction e.g. in MDS<\/li>\n\n\n\n<li>prophylaxis (1y or 2y)<\/li>\n<\/ul>\n\n\n\n<p><a href=\"https:\/\/hospital.blood.co.uk\/clinical-guidelines\/nhsbt-clinical-guidelines\/\">NHSBT clinical guidelines<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Granulocytes in England are unusual as they are provided as a component pooled from whole blood. Helen and Suzy discuss when their use should be considered and what to watch out for when using them Granulocyte component Pooled from 10 whole blood donations \u2192 buffy coats \u2192 red cell and platelet reduced \u2192 one bag [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1239,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[158],"tags":[103,132,125,122,124,136,123],"class_list":["post-1607","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-podcast","tag-blood","tag-blooducation","tag-foamed","tag-haematology","tag-nhs","tag-podcast","tag-podcasts"],"_links":{"self":[{"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/posts\/1607","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/comments?post=1607"}],"version-history":[{"count":1,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/posts\/1607\/revisions"}],"predecessor-version":[{"id":1608,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/posts\/1607\/revisions\/1608"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/media\/1239"}],"wp:attachment":[{"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/media?parent=1607"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/categories?post=1607"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/tags?post=1607"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}