{"id":1619,"date":"2026-03-14T13:05:27","date_gmt":"2026-03-14T13:05:27","guid":{"rendered":"https:\/\/blooducation.co.uk\/?p=1619"},"modified":"2026-03-14T13:05:38","modified_gmt":"2026-03-14T13:05:38","slug":"investigation-of-the-patient-with-a-panreactive-antibody-ruth-evans","status":"publish","type":"post","link":"https:\/\/blooducation.co.uk\/investigation-of-the-patient-with-a-panreactive-antibody-ruth-evans","title":{"rendered":"Investigation of the patient with a panreactive antibody &#8211; Ruth Evans"},"content":{"rendered":"\n<p><strong>Struggling to understand the difference between adsorptions and elutions? Ruth Evans from NHS Blood and Transplant talks Suzy through investigating the patient with a panreactive antibody.<\/strong><\/p>\n\n\n<p><iframe style=\"border: none;\" src=\"\/\/html5-player.libsyn.com\/embed\/episode\/id\/11354543\/height\/90\/theme\/custom\/thumbnail\/no\/direction\/backward\/render-playlist\/no\/custom-color\/87A93A\/\" width=\"100%\" height=\"90\" scrolling=\"no\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n\n\n<figure class=\"wp-block-image size-full\"><img fetchpriority=\"high\" decoding=\"async\" width=\"542\" height=\"460\" src=\"https:\/\/blooducation.co.uk\/wp-content\/uploads\/2019\/09\/Antibody_image.jpg\" alt=\"\" class=\"wp-image-968\" srcset=\"https:\/\/blooducation.co.uk\/wp-content\/uploads\/2019\/09\/Antibody_image.jpg 542w, https:\/\/blooducation.co.uk\/wp-content\/uploads\/2019\/09\/Antibody_image-300x255.jpg 300w, https:\/\/blooducation.co.uk\/wp-content\/uploads\/2019\/09\/Antibody_image-140x120.jpg 140w, https:\/\/blooducation.co.uk\/wp-content\/uploads\/2019\/09\/Antibody_image-70x60.jpg 70w, https:\/\/blooducation.co.uk\/wp-content\/uploads\/2019\/09\/Antibody_image-20x16.jpg 20w, https:\/\/blooducation.co.uk\/wp-content\/uploads\/2019\/09\/Antibody_image-150x127.jpg 150w\" sizes=\"(max-width: 542px) 100vw, 542px\" \/><\/figure>\n\n\n\n<p><strong>Learning points:<\/strong><\/p>\n\n\n\n<p>The direct antiglobulin test ascertains whether the patient has antibodies on their red cells in vivo. A positive test may be due to autoantibody or less frequently exogenous antibody (e.g. intravenous immunoglobulin, haemolytic disease of the newborn) or alloantibody on transfused cells.<\/p>\n\n\n\n<p>In the context of transfusion, autoantibodies are considered a nuisance! Adsorption studies are done in patients with autoantibodies in order to remove the antibody and establish whether there are any additional clinically significant alloantibodies present.<\/p>\n\n\n\n<p>Blood in people with autoantibodies is issued as \u201csuitable for\u201d as strictly it is not cross match compatible.&nbsp;\u201cLeast incompatible\u201d blood is only used when there is insufficient time for testing to be completed. No patient should die from lack of blood.<\/p>\n\n\n\n<p>Useful links<\/p>\n\n\n\n<p><a href=\"https:\/\/b-s-h.org.uk\/guidelines\/guidelines\/pre-transfusion-compatibility-procedures-in-blood-transfusion-laboratories\/\">BSH pre-transfusion compatibility procedures 2012 (with the 2017 update)<\/a><\/p>\n\n\n\n<p>Additional comments<\/p>\n\n\n\n<p>As we record we try to ensure we are as clear as possible. The following clarifications may be useful particularly for those revising for exams:-<\/p>\n\n\n\n<p>2:10&nbsp; &nbsp; &nbsp; &#8220;c and e&#8221; refer to anti-c and anti-e<\/p>\n\n\n\n<p>23:19&nbsp; &nbsp; &#8220;homozygously negative for different antigens&#8221; (rather than &#8220;cells&#8221;)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Struggling to understand the difference between adsorptions and elutions? Ruth Evans from NHS Blood and Transplant talks Suzy through investigating the patient with a panreactive antibody. Learning points: The direct antiglobulin test ascertains whether the patient has antibodies on their red cells in vivo. A positive test may be due to autoantibody or less frequently [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":798,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[158],"tags":[103,132,125,122,124,136,123],"class_list":["post-1619","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-podcast","tag-blood","tag-blooducation","tag-foamed","tag-haematology","tag-nhs","tag-podcast","tag-podcasts"],"_links":{"self":[{"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/posts\/1619","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/comments?post=1619"}],"version-history":[{"count":1,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/posts\/1619\/revisions"}],"predecessor-version":[{"id":1620,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/posts\/1619\/revisions\/1620"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/media\/798"}],"wp:attachment":[{"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/media?parent=1619"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/categories?post=1619"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/tags?post=1619"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}