{"id":1629,"date":"2026-03-14T13:16:52","date_gmt":"2026-03-14T13:16:52","guid":{"rendered":"https:\/\/blooducation.co.uk\/?p=1629"},"modified":"2026-03-14T13:17:02","modified_gmt":"2026-03-14T13:17:02","slug":"platelet-aggregometry-and-inherited-platelet-disorders-dr-gill-lowe","status":"publish","type":"post","link":"https:\/\/blooducation.co.uk\/platelet-aggregometry-and-inherited-platelet-disorders-dr-gill-lowe","title":{"rendered":"Platelet aggregometry and inherited platelet disorders &#8211; Dr Gill Lowe"},"content":{"rendered":"<h4>Familial ITP is very rare so if a FH exists, think about hereditary platelet disorders. Get historical plt counts and bleeding challenge history.<\/h4>\n<p><iframe style=\"border: none;\" src=\"\/\/html5-player.libsyn.com\/embed\/episode\/id\/13660154\/height\/90\/theme\/custom\/thumbnail\/no\/direction\/backward\/render-playlist\/no\/custom-color\/87A93A\/\" width=\"100%\" height=\"90\" scrolling=\"no\" allowfullscreen=\"allowfullscreen\"><\/iframe><\/p>\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"542\" height=\"460\" src=\"https:\/\/blooducation.co.uk\/wp-content\/uploads\/2021\/02\/Gill-Lowe.jpg\" alt=\"\" class=\"wp-image-1343\" style=\"width:450px;height:auto\" srcset=\"https:\/\/blooducation.co.uk\/wp-content\/uploads\/2021\/02\/Gill-Lowe.jpg 542w, https:\/\/blooducation.co.uk\/wp-content\/uploads\/2021\/02\/Gill-Lowe-300x255.jpg 300w, https:\/\/blooducation.co.uk\/wp-content\/uploads\/2021\/02\/Gill-Lowe-140x120.jpg 140w, https:\/\/blooducation.co.uk\/wp-content\/uploads\/2021\/02\/Gill-Lowe-70x60.jpg 70w, https:\/\/blooducation.co.uk\/wp-content\/uploads\/2021\/02\/Gill-Lowe-20x16.jpg 20w, https:\/\/blooducation.co.uk\/wp-content\/uploads\/2021\/02\/Gill-Lowe-150x127.jpg 150w\" sizes=\"(max-width: 542px) 100vw, 542px\" \/><\/figure>\n\n\n\n<p><strong>Investigations:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>FBC, film, coagulation, fibrinogen, von Willebrand screen, malaria screen, haematinics initially.<\/li>\n\n\n\n<li>Platelet function testing \u2013 PFA 100 &#8211; uses whole blood. 2 cartridges with differing agonists. Read out is the time for aperture closure.<\/li>\n\n\n\n<li>Light transmission aggregation testing \u2013 uses platelet rich and poor plasma. Individual agonists used in each cuvette (BSH guidance advises on profile to use). When the platelets aggregate, more light transmits through. Compare to control. Published normal reference ranges don\u2019t exist.<\/li>\n\n\n\n<li>Secretion assays.<\/li>\n\n\n\n<li>Flow cytometry for glycoprotein expression to confirm Glanzmanns and Bernard Soulier<\/li>\n\n\n\n<li>Genetics \u2013 haemostatic gene panel on NHS available later in the year.<\/li>\n<\/ul>\n\n\n\n<p>Conditions covered include storage pool disorders (alpha and dense), glycoprotein deficit disorders, MYH9 syndrome, TAR, Wiskott Aldrich.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" width=\"538\" height=\"624\" src=\"https:\/\/blooducation.co.uk\/wp-content\/uploads\/2020\/03\/agg-pic.png\" alt=\"\" class=\"wp-image-1220\" srcset=\"https:\/\/blooducation.co.uk\/wp-content\/uploads\/2020\/03\/agg-pic.png 538w, https:\/\/blooducation.co.uk\/wp-content\/uploads\/2020\/03\/agg-pic-259x300.png 259w, https:\/\/blooducation.co.uk\/wp-content\/uploads\/2020\/03\/agg-pic-300x348.png 300w, https:\/\/blooducation.co.uk\/wp-content\/uploads\/2020\/03\/agg-pic-150x174.png 150w, https:\/\/blooducation.co.uk\/wp-content\/uploads\/2020\/03\/agg-pic-20x23.png 20w\" sizes=\"(max-width: 538px) 100vw, 538px\" \/><\/figure>\n\n\n\n<p><strong>References:<\/strong><\/p>\n\n\n\n<p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2141.2011.08793.\">wiley.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Familial ITP is very rare so if a FH exists, think about hereditary platelet disorders. Get historical plt counts and bleeding challenge history. Investigations: Conditions covered include storage pool disorders (alpha and dense), glycoprotein deficit disorders, MYH9 syndrome, TAR, Wiskott Aldrich. References: wiley.com<\/p>\n","protected":false},"author":1,"featured_media":1233,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[158],"tags":[103,132,125,122,124,136,123],"class_list":["post-1629","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-podcast","tag-blood","tag-blooducation","tag-foamed","tag-haematology","tag-nhs","tag-podcast","tag-podcasts"],"_links":{"self":[{"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/posts\/1629","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/comments?post=1629"}],"version-history":[{"count":1,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/posts\/1629\/revisions"}],"predecessor-version":[{"id":1630,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/posts\/1629\/revisions\/1630"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/media\/1233"}],"wp:attachment":[{"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/media?parent=1629"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/categories?post=1629"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blooducation.co.uk\/api\/wp\/v2\/tags?post=1629"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}