Clinical use of granulocytes – Dr Suzy Morton

Granulocytes in England are unusual as they are provided as a component pooled from whole blood. Helen and Suzy discuss when their use should be considered and what to watch out for when using them Granulocyte component Pooled from 10 whole blood donations → buffy coats → red cell and platelet reduced → one bag […]

Advances in the classification and management of myelodysplasia – Dr Manoj Raghavan

Dr Manoj Raghavan speaks to Suzy about the 2016 revised WHO classification of MDS and gives some hints about what is likely to be coming in the revised BSH guideline.   Classification – see link below for full definitions. Cytopenias defined as haemoglobin <100g/L, platelet count <100 x109/L, neutrophils <1.8 x109/L. These differ to the […]

An overiew of CAR-T cell therapy – Dr Sridhar Chaganti

We are just at the start of what many are calling “the CAR-T cell revolution”. But what are CAR-T cells, how are they made, who can receive them and what are the draw-backs? Dr Sridhar Chaganti talks to Suzy Morton about haematology’s latest breakthrough. CAR-T = Chimeric Antigen Receptor T cells; T cells genetically modified […]

Appropriate use of O D neg blood – Dr Suzy Morton

O D negative blood is in demand, and use will always run higher than the proportion of donors, but why is it so crucial to maintain the supply and how can we make sure we are using it wisely? Helen talks to Dr Suzy Morton about the issues. O D neg donors comprise around 7% […]

Anticoagulation dilemmas – Dr Gill Lowe

Anticoagulation dilemmas with Dr Gill Lowe   References b-s-h.org.uk guidelines peri operative management of anticoagulation and antiplatelet therapy b-s-h.org.uk guidelines measurement of non-coumarin anticoagulants and their effects on tests of haemostasis rcog.org.uk guidelines ncibi.nlm.nih.gov The reversal of anticoagulation in clinical practice